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A recA-mediated recombination protocol in E.coli replaced the open reading frame of Atoh7 with a cre recombinase cassette with a nuclear localization signal (nls) and a polyA signal in the Atoh7-containing BAC RP23-38P3. The purified, linearized BAC construct was injected itno fertilized (SJL x C57BL/6J)F2 oocytes. 9 founders were obtained. Lines 872 and 360 were established and crossed to Z/AP reporter mice to assess cre activity. Line 360 was utilized in subsequent experiments. (J:184871)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
