Tg(Prnp*)#Rgab

The Syrian hamster promoter drives expression of the chimeric mouse/human cDNA MHu2M containing nucleotide substitutions that results in the amino acid substitutions of methionine for leucine at position 108, methionine for valine at position 111, methionine for isoleucine at position 138, asparagine for tyrosine at position 154, asparagine for serine at position 169 with the additional substitution of lysine for glutamic acid at position 199. This mutation corresponds to the human mutation E200K associated with Creutzfeldt-Jakob disease. Two lines were generated. The pound symbol (#) is used when no line is specified or lines or pooled. (J:183170)