An FRT flanked construct, consisting of a splice acceptor site, IRES-LacZ neo cassette and a pgk-BSD (blasticidin resistance gene) cassette, and a loxP site were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 4 via homologous recombination. Flp and cre mediated recombination removed the construct and exon 4, respectively. (J:183982)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count