A loxP-flanked neomycin resistance cassette with a thymidine kinase (TK) promoter was inserted between both exon 5 and 6, and exons 3 and 4. Cre-mediated recombination removed the neo cassette and left exon 4 and 5 floxed. (J:192124)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count