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The transgene consists of a mouse Ret cDNA encoding the RET9 isoform fused to mouse Hoxb7 promoter sequences (-1316 to +81). Mouse Hoxb7 promoter was used to drive expression of the transgene throughout the uretic bud branches. The construct retained all 201 bp of endogenous Ret9 non-coding sequences, including the out-of-frame upstream ATG at position 169, which presumably competes with the bonafide in-frame Ret9 initiation codon at position 201, resulting in a lower level of Ret9 protein. This construct does not generate dominant renal defects. (J:79420)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
