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Homologous recombination in E14 ES cells introduced a dominant negative Mastermind-like 1/EGFP fusion sequence ((Maml1/EGFP) into the Gt(ROSA)26Sor locus. An Frt-flanked neo cassette was also introduced with the targeting construct, and was subsequently deleted from germline chimeras by breeding them with Flpe-expressing mice. The dnMaml1 fusion protein is a potent inhibitor of the 4 mammalian Notch receptors. (J:184814)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
