A targeting vector was designed to insert a loxP site followed by an frt-flanked neomycin (neo) resistance cassette upstream of the promoter regions and exon 1, and a second loxP site downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:184670)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count