A loxP-flanked neomycin resistance cassette (neo) was inserted 3' of the coding sequence of Hoxb3 and was subsequently deleted by transient Cre recombinase mediated recombination in the targeted ES cells, leaving a single loxP site downstream of Hoxb3. Presence of the loxP site does not affect expression of the gene. (J:83563)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count