A cassette containing a IRES lacZ reporter construct and neomycin resistance gene was inserted in exon 1 via homologous recombination. Western blot analysis confirmed the absence of protein expression in E12.5 embryos. (J:183486, J:202343)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count