An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 11, and an additional loxP site was inserted downstream of exon 11. Flp-mediated recombination in ES cells removed the neo cassette, creating the floxed allele. (J:167711)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count