A loxP site was inserted in the promoter region 158 bp upstream of the transcription start site and an FRT flanked neo cassette and loxP site were inserted in intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette. Immunostaining confirmed normal expression of protein in the brain. (J:183467)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count