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This transgene expresses a kinase dead form of Akt1, with mutation at the ATP binding site that has been shown to act in a dominant negative manner, from the rat insulin 1 promoter. Immunofluorescence staining of pancreatic sections with anti-HA and anti-insulin antibodies showed that the majority of pancreatic beta cells (approximately 80 percent) expressed the transgene. Four transgenic founders were obtained and two lines were studied further, but no line numbers were given. (J:93417)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
