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This transgene expresses the human amyloidogenic immunoglobulin lambda 6 light chain and the bovine growth hormone polyadenylation sequence under the control of the cytomegalovirus (CMV) promoter. The lambda 6 light chain cDNA was generated by reverse transcription from RNA prepared from bone marrow collected from patient AL080 (GenBank sequence no. EF589388) who had rapidly progressive multiorgan amyloid light chain amyloidosis. (J:179082)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
