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This transgene contains a cDNA encoding the human cystic fibrosis transmembrane conductance regulator (CFTR) cloned into plasmid pUHD.10-3 between the PhCMV*-1 tetracycline-inducible promoter -- which is composed of a heptamer of the 19-base pair direct repeat tetracycline operator (tetO) followed by the human cytomegalovirus (CMV) immediate early (IE) minimal promoter, extending from nucleotide (nt) -53 to nt +75 -- and the SV40 polyadenylation signal. (J:169366)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
