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A loxP site and an Sph I site were inserted upstream of the distal enhancer element and the 450 bp proximal enhancer element was replaced with an FRT flanked neo cassette and a loxP site. Recombinase mediated recombination removed the neo cassette and a 3.1 kb region including the distal and the ectodermal enhancer elements. RT-PCR analysis indicates reduced pancreatic expression in homozygous mice at E15.5. (J:182769)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
