Dnai1^b2b1526Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to C substitution at coding nucleotide 1565 in exon 16 of the cDNA (c.1565T>C, NM_175138). This changes the isoleucine residue to threonine at position 522 of the encoded protein (p.I522T). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Dnai1b2b1526Clo, and may be present in stocks carrying this mutation.