Ltbp1^b2b1000Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to A substitution at coding nucleotide position 1134 in exon 7 of the cDNA (c.1134T>A, NM_206958). This changes the cysteine residue to a stop at position 378 of the encoded protein (p.C378*). Additional incidental mutations were detected in sequencing for the causative mutation, Ltbp1b2b1000Clo, and may be present in stocks carrying this mutation.