Smad6^b2b390Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a A to T substitution at coding nucleotide 982 in exon 4 of the cDNA (c.982A>T, NM_008542). This changes the lysine residue to a stop at position 328 of the encoded protein (p.K328*). Additional incidental mutations were detected in sequencing for the causative mutation, Smad6b2b390Clo, and may be present in stocks carrying this mutation.