RMCE on KH2 cells inserted a cassette, which contained a tetracycline response element driving doxycycline-inducible expression of the human cDNA with nucleotide substitutions that result in the amino acid substitution of alanine for serine at position 127 (S127A), into the 3'UTR. This mutation produces a protein with increased nuclear localization and transcriptional activity compared with the wild-type protein. (J:141457)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
Insertion
--
1
24
36

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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