LoxP sites were inserted around exon 2 and 3, which encode part of the DNA-binding domain. Flp-mediated recombination removed the FRT-flanked neo cassette located downstream of exon 3. (J:182210)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count