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A full length mouse Sox6 cDNA modified to append a human MYC tag to the carboxyl terminus of the protein product was cloned into the pEFneo vector downstream of the human eukaryotic elongation factor 1 alpha 1 promoter. Northern blot analysis using a Socs6 cDNA probe and western blot analysis with an anti-MYC antibody demonstrate that mice of line 1 express transgene-derived mRNA and protein, respectively, at 5-fold the levels expressed by wild-type mice from the endogenous gene in liver, muscle and T-lymphocytes. (J:181312)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
