Tab1^b2b449Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to A substitution at coding nucleotide 935 in exon 9 of the cDNA (c.935T>A, NM_025609). This changes the methionine residue to lysine at position 312 of the encoded protein (p.M312K). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Tab1b2b449Clo, and may be present in stocks carrying this mutation.