A loxP site was inserted upstream of exon 3 and a loxP and FRT flanked neo cassette was inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 3. Full length and TIVc isoform sequence and protein expression are absent in null mice. (J:181320)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Intragenic deletion
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--
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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