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A C to T mutation at postion 5995 resulting in a Arg2110Trp substitution was introduced in exon 31 and a floxed neo cassette was inserted in the intron between exons 31 and 32 via homologous recombination. Cre mediated recombination removed the neo cassette. Protein expression of P1a, but not P1c, is reduced in primary keratinocyte lysates from heterozygous and homozygous mice. (J:179812)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
