Dync2h1^b2b414Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to A substitution at coding nucleotide 701 in exon 5 of the cDNA (c.701T>A, NM_029851). This changes the valine residue to glutamic acid at position 234 of the encoded protein (p.V234E). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Dync2h1b2b414Clo, and may be present in stocks carrying this mutation.