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This transgene contains the 25-kDa C-terminal fragment of human TARDBP (encoding the last 199 amino acids) under the control of the Thy1.2 neuron specific regulatory sequence. Transgenic mice exhibit an accumulation of the 25-kDa fragment in the cytosolic fraction. Line B is the high expressing line and real-time PCR indicates 4.71 copies of the transgene in this line. (J:180165)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
