Igf2^tm4.1Wrk

A single loxP site interrupts the fourth of five HpaII sites within the LRRFIP1/GCF2 (leucine-rich repeat in FLII-interacting protein 1/GC-binding factor 2) repressor protein consensus binding sequence in the first differentially methylated region (DMR1 or Rr15) upstream of the imprinted insulin-like growth factor 2 gene. (J:178292)