Exon 4 was replaced with a splice acceptor, stop codon, IRES, bovine MAPT fused to lacZ (tau-lacZ) and floxed neo cassette. Cre-mediated recombination removed the neo cassette. Immunofluorescence confirmed the absence of protein expression. (J:181058)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count