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This transgene contains the mouse Thy1 (thymus cell antigen 1, theta, promoter (Thy1.2)) promoter driving expression of the full-length human dynactin 1 (DCTN1) cDNA sequence. A missense mutation associated with amyotrophic lateral sclerosis (ALS), G59S, was introduced into dynactin cDNA encoding the p150 subunit. A FLAG tag was also introduced at the C-terminal. Line M2 was generated. (J:132857)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
