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A 3 nucleotide (AAG) deletion that removes lysine 32 was introduced into exon 1 and a floxed neo-cre cassette was inserted into intron 1 via homologous recombination. The neo-cre cassette is self-excising in the male germ line. In homozygous mice protein expression of lamin A/C is reduced in skeletal muscles and it fails to relocalize to the nuclear periphery in developing embryos at E17.5. (J:180603)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
