This mutation was induced by retroviral transduction of ES cells with the U3betageo gene trap vector, which contains a promoterless E. coli beta-galactosidase (lacZ)/neomycin phosphotransferase fusion gene (betageo) without a splice acceptor sequence. Its insertion has disrupted intron 5 of the endogenous gene. (J:82809)
Basic Information
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count