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A 590 kb deletion was induced by cre mediated recombination between Is(2)46Ddu and Atf2tm3Nicj . The deletion encompasses the entire gene desert upstream of Lnp and part of Atf2. At E12.5 mRNA expression levels of Lnp, Evx2, Hoxd13, Hoxd12, Hoxd11, and Hoxd10 are reduced to about 20% of wild-type levels in the developing digits. (J:178930, J:192248)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
