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A 300 kb deletion was induced by cre mediated recombination between Is(2)46Ddu and Tn(sb-SBlac)C.176599bFsp . The deletion encompasses the proximal half of the gene desert upstream of Lnp and does not include the global control region (GCR) that modifies expression of the Hoxd genes. At E12.5 mRNA expression of Hoxd13 and Hoxd12 was reduced to 70% of wild-type in the developing autopod. (J:178930)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
