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EN
Exon 2 was replaced with a floxed neo cassette and a modified exon 2 with nucleotide substitutions that result in the amino acid substitutions of arginine for lysine at positions 219, 242, 245, 259, 262, 271, 291 (K219R, K242R, K245R, K259R, K262R, K271R, and K291R). These mutations produce a constitutively deacetylated allele. Cre-mediated recombination removed the neo cassette. (J:179687)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
