A loxP site was inserted upstream of exon 11 and a loxP and FRT flanked neo cassette was inserted downstream of exon 11 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 11 floxed. (J:178827)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count