A targeting vector was designed to replace the start codon of the cyclin E1 (Ccne1) gene with a Flag-HA tag. A loxP-flanked hygromycin (hyg) selection cassette was inserted downstream of exon 3. Cre-mediated recombination removed the hygro cassette. (J:178882)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count