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A beta-Actin-Neo and HSC-tk sequence was inserted into the BglII site in the last exon of the Nkx2-5 gene in v6.5 ES cells. A population of properly targeted ES cells was exposed to 4Gy of radiation from a Cesium- 137 source. Deletion mutants were selected in ES cells by restoration of "tk" sensitivity. Four mouse stocks and 11 mutated ES cell lines were established. (J:86784, J:99488)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
