Rax^tm1.1Tfur

A targeting vector was used to insert flox sites upstream of exon 1 and intron 2 by homologous recombination in ES cells. An Frt-flanked PGK-neo selection cassette was inserted also, and removed after selection of correctly targeted clones by Flp recombinase. Cre-mediated recombination will result in excision of exons 1 and 2 of Rax, producing a null allele. (J:177908)