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The transgene construct was generated by BAC recombineering methods in bacteria. The Kcne1 (minK) coding sequence in BAC RP23276-120 was replaced with a cre/ERT2-bGH pA-Frt-Zeo-Frt cassette. The purified BAC was microinjected into fertilized CD-1 oocytes. Four founder lines that exhibited consisted inducible cre activity in the cardiac conduction were obtained. One line was analyzed in greater detail. Line numbers are not available. (J:178662)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
