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A 780 bp fragment corresponding to the region immediately 5' to the start codon of the Cpa3 gene was used to drive expression of cre recombinase in the transgene construct. The Cpa3-cre construct was microinjected into C57BL/6-derived embryonic stem (ES) cells. Analysis of mice generated in crosses of cre transgenic to dual reporter (mT/mG) animals showed that most (about 89%) of peritoneal mast cells exhibit high levels of recombination whereas only 13-15% of granulocytes (basophils, eosinophils and neutrophils) display significant recombination. (J:179080)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
