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The transgenic construct contains three amino acid substitutions (Leu374Ala, Val375Ala, and Phe376Ala) introduced into the mouse retinal S-antigen (arrestin; (GenBank M24086)) coding sequence under the direction of the mouse rod opsin promoter. Line 1 and 2 with moderate and high expression were generated from founders 3A50 and 3A240, respectively. (J:99855)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
