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The transgenic construct contains rat 11beta-HSD2 cDNA (Hsd11b2) gene, and was cloned downstream of a 2.3-kb fragment of the rat Col1a1 promoter and upstream of the bovine GH polyadenylation sequence. Three independent lines were established, 515, 516 and 529. The transgene was expressed in calvariae, long bone, vertebrae, and tail of transgenic mice. (J:96387)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
