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A targeting construct was electroporated into ES cells and by homologous recombination, a tTA-Frt-neo-Frt (tTA = tetracycline transactivator) sequence was inserted into the second coding exon of Pparg, creating an in-frame fusion between the amino terminus of Pparg and tTA. Correctly targeted ES cells were used to generate mice. The neo resistance cassette was removed from the germline by crossing Pparg mutants with FLPe-expressing mice. (J:178521, J:212531)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
