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A C to T point mutation was introduced into the gene coding for the third C domain of the mu-heavy chain causing the amino acid encoded by codon 436 to change from proline to serine. A floxed neomycin was inserted as well. This neo cassette was subsequently excised from correctly targeted mice. (J:177421, J:178135, J:178136)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
