Acan^b2b183Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to A substitution at coding nucleotide 1032 in exon 6 of the cDNA (c.1032T>A, NM_007424). This changes the tyrosine residue to a translation stop at position 344 of the encoded protein (p.Y344*). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Acanb2b183Clo, and may be present in stocks carrying this mutation.