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EN
A cDNA encoding amino acids 89-665 was inserted into exon 2, in which nucleotide substitutions that results in the amino acid substitution of phenylalanine for tyrosine at positions 441, 465, and 573 (Y441F, Y465F, Y573F) abolishing the PI3K-binding domain. A floxed neo cassette inserted downstream of exon 2 was removed by cre-mediated recombination. (J:178045)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
