Recombinase mediated cassette exchange was used to insert two short hairpin RNAi specific for the Brachyury (T) gene under the control of tetO followed by a PGK promoter into the Gt(ROSA)26Sortm2Bgh allele. Expression of the shRNAi requires treatment with doxycycline. (J:173434)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count