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An EGFP expression cassette as well as an FRT flanked neomycin resistance gene was inserted into the Mir144 hairpin. The EGFP construct includes a synthetic intronic sequence and the strong late polyadenylation signal from SV40. The selection gene was excised by crossing to flp deleter mice. Insertion of the EGFP reporter in Mir144 disrupts expression of both Mir144 and Mir451 which are transcribed as a single precursor RNA. (J:177074)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
