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A targeting construct encoding a cre recombinase/mutated estrogen ligand binding-domain (cre/ERT2) fusion sequence and an Frt-flanked neo cassette was targeted to the Sox2 locus in V6.5 ES cells, so that cre was under control of endogenous Sox2 regulatory elements. Chimeric mice were bred to 129/SvJae wild-type animals to test for germline transmission and to establish stable lines. (J:177655)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
