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This transgene consists of the murine Gata1 cDNA with a V205G (GTG to GGG) mutation under the control of the Gata1 genomic locus spanning 3.9 kb 5' of the hematopoietic IE exon to the second exon (GATA-1 HRD) which recapitulates endogenous Gata1 gene expression. The valine 205 to glycine substitution has been shown to reduce Zfpm1 (Fog-1) association. Five lines were made. This line is a high-expressing line. (J:89054)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
